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Dermatol Surg. 2006 Oct;32(10):1219-30.

Retinoids and wound healing.

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1
Department of Dermatology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19107, USA. markabdelmalek@gmail.com

Abstract

BACKGROUND:

Retinoids are widely used in dermatology and may play a role in wound healing. The exact role of retinoids in wounds is confusing and controversial, however. Systemic retinoids are presumed to be detrimental to wound healing; however, this standard is based on isolated reports.

OBJECTIVE:

The objective was to provide a critical review of the available literature regarding the role of both topical and systemic retinoids in various aspects of wound healing.

CONCLUSIONS:

Pretreatment with retinoids likely promotes wound healing after facial resurfacing procedures and full- or partial-thickness wounds. While the evidence is mixed regarding the effects of retinoids applied to fresh and healing wounds, the majority of the evidence available shows favorable wound-healing properties in this setting. The medical-legal standard regarding the avoidance of facial resurfacing and surgical procedures in patients on or recently completing a course of systemic retinoids was likely prematurely established.

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