Format

Send to

Choose Destination
Nano Lett. 2006 Oct;6(10):2225-31.

In vivo molecular probing of cellular compartments with gold nanoparticles and nanoaggregates.

Author information

1
Wellman Center for Photomedicine, Harvard University, Medical School, Boston, Massachusetts 02114, USA. jkneipp@janina-kneipp.de

Abstract

Surface-enhanced Raman (SERS) signatures were measured from single living cells at different times after the uptake of gold nanoparticles. The spectra are indicative of chemical changes in the environment of the nanostructures over time. The increase of the SERS signal strength and parallel TEM studies indicate the formation of nanoaggregates providing optimum SERS enhancement for ultrasensitive probing inside the endosomal compartment. The results have implications for medical and biotechnology applications of SERS nanosensors in cells.

PMID:
17034088
DOI:
10.1021/nl061517x
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for American Chemical Society
Loading ...
Support Center