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Qual Life Res. 2007 Mar;16(2):331-43. Epub 2006 Oct 11.

The development of a new measure of quality of life in the management of gastro-oesophageal reflux disease: the Reflux questionnaire.

Author information

1
Outcomes Research Group, Centre for Health Economics, University of York, Heslington, York, YO10 5DD, United Kingdom. sm37@york.ac.uk

Abstract

INTRODUCTION:

This paper reports on the development of a new measure of health-related quality of life for use among patients with gastro-oesophageal reflux disease (GORD), funded as part of the REFLUX trial. This is a large UK multi centre trial that aims to compare the clinical and cost effectiveness of minimal access surgery with best medical treatment for patients with GORD within the NHS.

METHOD:

Potential items were identified via a series of interviews and focus groups carried out with patients who were receiving/had received medical or surgical treatment for GORD. The final measure consisted of 31 items covering 7 categories (Heartburn; Acid reflux; Wind; Eating and swallowing; Bowel movements; Sleep; Work, physical and social activities). The measure produced two outputs: a quality of life score (RQLS) and five Reflux symptom scores. Reliability (internal consistency), criterion validity with the SF-36 and, sensitivity to change in terms of relationship with reported change in prescribed medication were assessed amongst a sample of 794 patients recruited into the trial.

RESULTS:

The measure was shown to be internally consistent, to show criterion validity with the SF-36 and sensitive to changes in patients use of prescribed medication at baseline and 3 month follow-up.

DISCUSSION:

The Reflux questionnaire is a new self-administered questionnaire for use amongst patients with GORD. Initial findings suggest that the new measure is valid, reliable, acceptable to respondents and simple to administer in both a clinical and research context.

PMID:
17033907
DOI:
10.1007/s11136-006-9005-3
[Indexed for MEDLINE]

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