FGF1/p38 inhibitor treatment increases angiogenesis. (A) FGF1/p38i and FGF1, but not p38i, significantly increased angiogenesis of the scar area at 3 months. (B) Examples of vessel staining 3 months after MI using vessel markers smooth muscle actin (SMA, smooth muscle cells, fluorescent green) and von Willebrand factor (vWF, endothelial cells, red) and cardiomyocyte-specific marker Caveolin 3 (pale green). (C) Examples of vessel staining of heart sections from rats 3 months after coronary ligation treated with FGF1/p38i. Data are ±SEM; n ≥ 7 in each group; NS, not significant; ∗, P < 0.05; ∗∗, P < 0.01.