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Am J Gastroenterol. 2006 Oct;101(10):2263-8.

Risk factors for gallstone-related hospitalization during pregnancy and the postpartum.

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1
Department of Medicine, University of Washington, Seattle, Washington 98195, USA.

Abstract

OBJECTIVES:

Gallbladder disease is a leading nonobstetrical cause for hospitalization in the first year postpartum. The aim of this study was to define the incidence and risk factors for postpartum hospitalization as a result of gallstone-related disease.

METHODS:

We identified 6,670 women with discharge diagnoses related to biliary disease from linked birth certificate and hospital discharge databases for Washington State from 1987 through 2001. Cases were women with gallstone-related diagnoses at delivery or as primary diagnosis in the postpartum. Four controls who were within 1 yr postpartum were randomly selected for each case and matched for year of delivery. From the birth certificates, we obtained data about patient demographics, reproductive history, and pregnancy-related risk factors. In a retrospective case-control study, we developed multiple logistic regression models to identify independent risk factors for hospitalization.

RESULTS:

We identified 6,211 women as cases (0.5% of all births) during the study period. The median time to hospitalization was 95 days (interquartile range 46-191 days), with a median length of stay of 3 days. Seventy-six percent were diagnosed with uncomplicated cholelithiasis, 16% with pancreatitis, 9% with acute cholecystitis, and 8% with cholangitis. Seventy-three percent of hospitalized women underwent cholecystectomy, and 5% underwent endoscopic retrograde cholangiopancreatography (ERCP). On multivariate analysis, independent risk factors for hospitalization included maternal race, age, being overweight or obese prepregnancy, pregnancy weight gain, and estimated gestational age.

CONCLUSIONS:

Hospitalization for gallstone-related disease is common in the first year postpartum, most commonly for uncomplicated cholelithiasis. Risk factors for hospitalization include prepregnancy body mass index, race, Hispanic ethnicity, and maternal age.

[Indexed for MEDLINE]

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