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Prostate. 2007 Jan 1;67(1):50-60.

In vivo imaging of prostate cancer involving bone in a mouse model.

Author information

1
Department of Radiology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA. vkundra@di.mdacc.tmc.edu

Abstract

BACKGROUND:

We compared the abilities of clinically relevant imaging modalities to quantify prostate cancer involving bone in a mouse model. Such non-invasive methods are needed pre-clinically to understand tumor biology and to evaluate therapy.

METHODS:

Human prostate cancer cells (MDA PCa 2b) or vehicle were injected into the right or left femur of SCID mice (n = 8). Radiography, computed tomography, and magnetic resonance imaging were performed 5 and 8 weeks later (n = 7). Bone scintigraphy (n = 6) was also performed at week 8. Imaging findings were compared with histology and correlated with contemporaneous serum prostate-specific antigen levels.

RESULTS:

Among the modalities evaluated, only MR imaging delineated prostate tumors involving bone. Tumor volume assessed by MR imaging correlated with PSA levels (R(2) = 0.87, P < 0.001). MR imaging of tumors corresponded with histology. Imaging of mineralized bone by CT corresponded with histology.

CONCLUSION:

In a mouse model, prostate tumors involving bone can be quantified using MR imaging.

PMID:
17031813
DOI:
10.1002/pros.20494
[Indexed for MEDLINE]

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