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Pflugers Arch. 2007 Mar;453(6):753-62. Epub 2006 Oct 10.

Regulation of TRP channels by PIP(2).

Author information

1
Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, NJ 07103, USA. tibor.rohacs@umdnj.edu

Abstract

Transient receptor potential (TRP) channels are regulated by a wide variety of physical and chemical factors. Recently, several members of the TRP channel family were reported to be regulated by phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2), PIP(2)). This review will summarize the current knowledge on PIP(2) regulation of TRP channels and discuss the possibility that PIP(2) is a common regulator of mammalian TRP channels.

PMID:
17031667
DOI:
10.1007/s00424-006-0153-7
[Indexed for MEDLINE]

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