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Obesity (Silver Spring). 2006 Sep;14(9):1562-70.

Physiological evidence for the involvement of peptide YY in the regulation of energy homeostasis in humans.

Author information

1
Obesity and Diabetes Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA. yanguo@phx.niddk.nih.gov

Abstract

OBJECTIVE:

To explore the potential role of the endogenous peptide YY (PYY) in the long-term regulation of body weight and energy homeostasis.

RESEARCH METHODS AND PROCEDURES:

Fasting and postprandial plasma PYY concentrations were measured after an overnight fast and 30 to 180 minutes after a standardized meal in 29 (21 men/8 women) non-diabetic subjects, 16 of whom had a follow-up visit 10.8 +/- 1.4 months later. Ratings of hunger and satiety were collected using visual analog scales. Resting metabolic rate (RMR) (15-hour RMR) and respiratory quotient (RQ) were assessed using a respiratory chamber.

RESULTS:

Fasting PYY concentrations were negatively correlated with various markers of adiposity and negatively associated with 15-hour RMR (r = -0.46, p = 0.01). Postprandial changes in PYY (area under the curve) were positively associated with postprandial changes in ratings of satiety (r = 0.47, p = 0.01). The maximal PYY concentrations achieved after the meal (peak PYY) were negatively associated with 24-hour RQ (r = -0.41, p = 0.03). Prospectively, the peak PYY concentrations were negatively associated with changes in body weight (r = -0.58, p = 0.01).

DISCUSSION:

Our data indicate that the endogenous PYY may be involved in the long-term regulation of body weight. It seems that this long-term effect was not exclusively driven by the modulation of food intake but also by the control of energy expenditure and lipid metabolism.

PMID:
17030967
DOI:
10.1038/oby.2006.180
[Indexed for MEDLINE]
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