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Infect Immun. 2007 Jan;75(1):504-7. Epub 2006 Oct 9.

Signature-tagged transposon mutagenesis identifies novel Mycobacterium tuberculosis genes involved in the parasitism of human macrophages.

Author information

1
Unit of Mycobacterial Genetics, Institut Pasteur, Paris, France.

Abstract

Using signature-tagged transposon mutagenesis, we isolated 23 Mycobacterium tuberculosis mutants, corresponding to 21 genes or genetic regions, attenuated in their ability to parasitize human macrophages. Mutants disrupted in the ABC transporter-encoding genes Rv0986 and Rv0987 were further characterized as being impaired in their ability to bind to host cells.

PMID:
17030567
PMCID:
PMC1828433
DOI:
10.1128/IAI.00058-06
[Indexed for MEDLINE]
Free PMC Article

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