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J Allergy Clin Immunol. 2006 Oct;118(4):938-41. Epub 2006 Aug 28.

Mumps resurgence in the United States.

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Allergy/Immunology Section, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, USA.


The recent mumps epidemic in the central United States has generated a large amount of public concern. A total of 2597 mumps cases have been reported in the United States in 11 states since January 1, 2006, representing a marked resurgence of mumps in a single year. The majority of these recent cases have occurred in college students age 18 to 25 years. Most were vaccinated with 2 doses of measles, mumps, and rubella-containing vaccines. Such outbreaks provide an opportunity for clinicians to review the clinical presentation, diagnosis, and morbidity of vaccine-preventable infections and also to review immunologic mechanisms and practice guidelines that might contribute to poor vaccine responses. A review of mumps is provided with discussion of potential mechanisms for vaccine failure.

[Indexed for MEDLINE]

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