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J Struct Biol. 2007 May;158(2):137-47. Epub 2006 Aug 23.

Structure and thermodynamics of the tubulin-stathmin interaction.

Author information

1
Biomolecular Research, Structural Biology, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland. michel.steinmetz@psi.ch

Abstract

Oncoprotein 18/stathmin (stathmin) is a phosphorylation-controlled key regulator of microtubule dynamics. In recent years, substantial efforts were undertaken to characterize the complex formed between tubulin and the intrinsically disordered stathmin molecule. Here, I summarize and illustrate the current structural and thermodynamic studies on the tubulin-stathmin interaction. Based on these and on functional information I formulate an updated molecular mechanism on how tubulin-binding by stathmin regulates microtubule dynamics.

PMID:
17029844
DOI:
10.1016/j.jsb.2006.07.018
[Indexed for MEDLINE]

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