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Trends Biochem Sci. 2006 Nov;31(11):597-601. Epub 2006 Oct 6.

Store-operated Ca2+ entry: A STIMulating stOrai.

Author information

1
Department of Pharmacology, University of Cambridge, Cambridge, CB2 1PD, UK. cwt1000@cam.ac.uk

Abstract

Store-operated Ca2+ entry (SOCE) mediates much of the Ca2+ entry evoked by receptors that stimulate phospholipase C. However, for 20 years, the plasma membrane Ca2+ channel and the signal linking its activation to loss of Ca2+ from the endoplasmic reticulum (ER) have eluded detection. But the search might now be over. Two proteins, STIM1 (the ER Ca2+ sensor) and Orai1 (the Ca2+ channel), have recently been identified as the missing links in SOCE.

PMID:
17029812
DOI:
10.1016/j.tibs.2006.09.007
[Indexed for MEDLINE]

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