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Oncogene. 2006 Oct 9;25(46):6156-62.

Principles of micro-RNA production and maturation.

Author information

1
Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA. zengx033@umn.edu

Abstract

Micro-RNAs (miRNAs) are a class of approximately 22-nucleotide non-coding RNAs expressed in multicellular organisms. They are first transcribed in a similar manner to pre-mRNAs. The transcripts then go through a series of processing steps, including endonucleolytic cleavage, nuclear export and a strand selection procedure, to yield the single-stranded mature miRNA products. The transcription and processing of miRNAs determines the abundance and the sequence of mature miRNAs and has important implications for the function of miRNAs.

PMID:
17028594
DOI:
10.1038/sj.onc.1209908
[Indexed for MEDLINE]

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