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Rev Neurol (Paris). 2006 Oct;162(10):990-6.

[Late onset forms of myasthenia gravis. Comparison with early-onset myasthenia gravis].

[Article in French]

Author information

1
Service de Neurologie A et Maladies Neurovasculaires, CHU Gui de Chauliac, Montpellier, France.

Abstract

INTRODUCTION:

The incidence of myasthenia gravis appears to be increasing in elderly but few studies have been devoted to late onset myasthenia gravis.

PATIENTS AND METHODS:

We retrospectively compared myasthenic patients with an age at onset above or below 35 years which were observed in two departments of Neurology from 1980 to 2002.

RESULTS:

81 cases were included, 28 of which were late onset myasthenia gravis. The two populations were similar in terms of sex-ratio, clinical symptoms, course of the disease and therapeutic response. There was a trend for older patients to present more frequently at onset with dysphagia and axial or proximal involvement, and to have extra-ocular symptoms more quickly. Antibodies against acetylcholine receptor and striated muscle were statistically more frequent in elder patients.

CONCLUSIONS:

A late onset is not a factor of poor prognosis in myasthenia gravis and older patients must be treated in the same way than younger ones.

PMID:
17028567
[Indexed for MEDLINE]
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