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Respiration. 2007;74(1):61-8. Epub 2006 Oct 4.

Prednisone blunts airway neutrophilic inflammatory response due to ozone exposure in asthmatic subjects.

Author information

1
Pneumology Section, Cardiothoracic Department, University of Pisa, Pisa, Italy. b.vagaggini@ao-pisa.toscana.it

Abstract

BACKGROUND:

The effect of corticosteroids on the ozone (O3)-induced airway inflammation is still debated.

OBJECTIVE:

The aim of the study was to confirm the effect of a short-term treatment with oral glucocorticosteroids on O3-induced airway inflammation, detected by induced sputum analysis, and on functional response in glucocorticosteroid-naive subjects.

METHODS:

A randomized, placebo-controlled study using oral prednisone (25 mg o.d. for 4 days) was carried out. Nine mild persistent asthmatics were exposed for 2 h, on separatedays, to 0.27 ppm O3 and to air in random order, after 4 days of treatment with prednisone (25 mg o.d.) and after 4 days of placebo.Before and after exposure, pulmonary function test was measured; 6 h afterexposure, sputum induction was done.

RESULTS:

Oral glucorticosteroids did not prevent pulmonary function decrement due to O3. After placebo, the percentage of neutrophils in induced sputum was significantly higher after O3 than after air [52.1 (15.7-77.3) vs. 17.8 (1.7-58.4), p=0.02, O3 vs. air]. This difference was lost after 4 days of treatment with prednisone [35.2% (10-96.2) vs. 30.9% (6.1-75.6), n.s., O3 vs. air]. Neutrophil elastase in sputum supernatant increased after O3 exposure in the sample obtained after placebo, but not after prednisone treatment.

CONCLUSIONS:

This study confirms that glucocorticosteroids reduce inflammatory airway response, but do not prevent the airway functional impairment after O3 exposure.

PMID:
17028419
DOI:
10.1159/000096078
[Indexed for MEDLINE]

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