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J Bacteriol. 2006 Dec;188(24):8649-54. Epub 2006 Oct 6.

nalD encodes a second repressor of the mexAB-oprM multidrug efflux operon of Pseudomonas aeruginosa.

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  • 1Department of Microbiology & Immunology, Queen's University, Kingston, ON, Canada K7L 3N6.

Abstract

The Pseudomonas aeruginosa nalD gene encodes a TetR family repressor with homology to the SmeT and TtgR repressors of the smeDEF and ttgABC multidrug efflux systems of Stenotrophomonas maltophilia and Pseudomonas putida, respectively. A sequence upstream of mexAB-oprM and overlapping a second promoter for this efflux system was very similar to the SmeT and TtgR operator sequences, and NalD binding to this region was, in fact, demonstrated. Moreover, increased expression from this promoter was seen in a nalD mutant, consistent with NalD directly controlling mexAB-oprM expression from a second promoter.

PMID:
17028276
PMCID:
PMC1698243
DOI:
10.1128/JB.01342-06
[PubMed - indexed for MEDLINE]
Free PMC Article
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