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Eur J Pharmacol. 2006 Dec 3;551(1-3):76-9. Epub 2006 Sep 12.

Nicotine administration enhances conditioned inhibition in rats.

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1
Department of Psychological and Brain Sciences, Dartmouth College, 6207 Moore Hall, Hanover, NH 03755, USA.

Abstract

The effect of nicotine on conditioned inhibition was examined using a serial feature negative discrimination task. Nicotine (0.35 mg/kg) or vehicle was administered before each of the 16 training sessions. On some trials in each session, a tone was presented and followed by food reward. On other trials, the tone was preceded by a visual stimulus and not reinforced. Nicotine-treated rats exhibited greater discrimination between the two trial types as evidenced by less frequent responding during non-reinforced trials, and learned the discrimination in fewer sessions than vehicle-treated rats. In contrast, there were no group differences in responding during the reinforced trials.

PMID:
17027751
PMCID:
PMC1829413
DOI:
10.1016/j.ejphar.2006.08.082
[Indexed for MEDLINE]
Free PMC Article
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