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Curr Opin Pharmacol. 2006 Dec;6(6):586-91. Epub 2006 Oct 5.

Cannabinoid receptors as therapeutic targets for obesity and metabolic diseases.

Author information

1
Endocrinology Unit and CRBA, Department of Internal Medicine and Gastroenterology, S. Orsola-Malpighi Hospital, Via Massarenti 9, 40138 Bologna, Italy.

Abstract

One of the most interesting pharmacological targets proposed in the past ten years for fighting obesity and related metabolic disorders is the endocannabinoid system. The role of the endocannabinoid system is crucial in regulating the rewarding properties of food, in controlling energy balance by acting at the hypothalamic circuitries involved in food intake, and in peripheral metabolism by influencing adipocytes, hepatocytes, myocytes and pancreatic endocrine cells. Obesity seems to be a condition associated with a pathological overactivation of the endocannabinoid system; therefore, restoring a normal endocannabinoid tone by antagonizing the cannabinoid receptor type 1 (CB(1)) could help arrest both the development and the maintenance of obesity.

PMID:
17027338
DOI:
10.1016/j.coph.2006.09.001
[Indexed for MEDLINE]

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