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Am J Obstet Gynecol. 2006 Dec;195(6):1826-31. Epub 2006 Oct 5.

Histological and biomechanical evaluation of implanted graft materials in a rabbit vaginal and abdominal model.

Author information

1
Division of Gynecologic Surgery, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA. hilger.wesley@mayo.edu

Abstract

OBJECTIVE:

The objective of the study was to describe the histologic and biomechanical changes of implanted dermal collagen graft materials.

STUDY DESIGN:

Twenty rabbits were randomized into 2 groups (6 and 12 weeks, respectively). Each rabbit had 4 graft segments (human dermis, porcine dermis, porcine collagen-coated polypropylene mesh, and autologous fascia) randomly implanted into the abdomen and the vagina. Biomechanical testing and histologic analysis was performed after recovery of graft segments.

RESULTS:

Dermal graft segments showed a marked decrease in ultimate strength (84% to 86%) and elastic modulus (73% to 82%) that was significantly different from the decrease seen in autologous fascia or coated synthetic mesh (P < .0008 and P < .0001, respectively). The decrease in ultimate strength was associated with vaginal implantation (P = .057). Dermal graft materials had moderate inflammation and minimal collagen infiltration.

CONCLUSION:

The mechanical properties of dermal graft materials decline after implantation. Vaginal implantation may cause a different tissue response to graft material than abdominal implantation. Dermal graft material caused moderate inflammation and minimal collagen ingrowth remote from implantation.

PMID:
17026951
DOI:
10.1016/j.ajog.2006.07.006
[Indexed for MEDLINE]
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