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Zh Vyssh Nerv Deiat Im I P Pavlova. 2006 Jul-Aug;56(4):543-7.

[Alteration of active and passive Wistar rats adaptive behavior in water-immersion model of depression].

[Article in Russian]


Animals with active and passive behavioral strategy were selected among male Wistar rats by testing them in the T-maze. Using the results of rats testing in T-maze index of behavioral activity and index of behavioral passivity were calculated. The development of post-stress psychopathology and ils correlation with initial behavioral strategy were studied under water-immersion stress conditions consiclering individual alteration of adaptive behavior. Two paradigms were used--one time trial (stress) and two times trial (stress-restress). It was found that active and passive rats being subjected to inescapable aversive exposure develop different types of post-stress depression and only passive animals show the signs of posttraumatic stress disorder.

[Indexed for MEDLINE]

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