Format

Send to

Choose Destination
See comment in PubMed Commons below
Arch Pharm Res. 2006 Sep;29(9):746-51.

Antifungal effect of amentoflavone derived from Selaginella tamariscina.

Author information

1
Department of Microbiology, College of Natural Sciences, Kyungpook National University, Daegu 702-701, Korea.

Abstract

Amentoflavone is a plant bif avonoid that was isolated from an ethyl acetate extract of the whole plant of Selaginella tamariscina (Beauv.) spring. 1D and 2D NMR spectroscopy including DEPT, HMQC, and HMBC were used to determine its structure. Amentoflavone exhibited potent antifungal activity against several pathogenic fungal strains but had a very low hemolytic effect on human erythrocytes. In particular, amentoflavone induced the accumulation of intracellular trehalose on C. albicans as a stress response to the drug, and disrupted the dimorphic transition that forms pseudo-hyphae during pathogenesis. In conclusion, amentoflavone has great potential to be a lead compound for the development of antifungal agents.

PMID:
17024847
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center