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Science. 2006 Oct 6;314(5796):133-6.

Infectious prions in the saliva and blood of deer with chronic wasting disease.

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1
Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biological Sciences (CVMBS), Colorado State University (CSU), Fort Collins, CO 80523, USA.

Abstract

A critical concern in the transmission of prion diseases, including chronic wasting disease (CWD) of cervids, is the potential presence of prions in body fluids. To address this issue directly, we exposed cohorts of CWD-naïve deer to saliva, blood, or urine and feces from CWD-positive deer. We found infectious prions capable of transmitting CWD in saliva (by the oral route) and in blood (by transfusion). The results help to explain the facile transmission of CWD among cervids and prompt caution concerning contact with body fluids in prion infections.

PMID:
17023660
DOI:
10.1126/science.1132661
[Indexed for MEDLINE]
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