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J Mol Med (Berl). 2006 Dec;84(12):997-1003. Epub 2006 Oct 5.

Thioredoxin in the cardiovascular system.

Author information

1
Cardiovascular Research Institute, Department of Medicine, University of Rochester, Rochester, NY, USA.

Abstract

The thioredoxin (TRX) system (TRX, TRX reductase, and NADPH) is a ubiquitous thiol oxidoreductase system that regulates cellular reduction/oxidation (redox) status. The impairment of cell redox state alters multiple cell pathways, which may contribute to the pathogenesis of cardiovascular disorders including hypertension, atherosclerosis, and heart failure. In this manuscript, we review the essential roles that TRX plays by limiting oxidative stress directly via antioxidant effects and indirectly by protein-protein interactions with key signaling molecules such as thioredoxin interacting protein (TXNIP). TRX and its endogenous regulators may represent important future targets to develop clinical therapies for diseases associated with oxidative stress.

PMID:
17021908
DOI:
10.1007/s00109-006-0109-6
[Indexed for MEDLINE]

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