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Cell. 2006 Oct 6;127(1):35-7.

Cargo takes control of endocytosis.

Author information

1
Institute of Chemistry and Biochemistry, Laboratory of Membrane Biochemistry, Freie Universit├Ąt Berlin, Takustrasse 6, 14195 Berlin, Germany. vhaucke@chemie.fu-berlin.de

Abstract

Clathrin-mediated endocytosis is a major route for diverse cargo to enter the cellular endocytic pathway. New findings by Puthenveedu and von Zastrow (2006) suggest that certain cargo proteins, such as G protein coupled receptors that bind to PDZ domains, regulate their own targeting to a subset of clathrin-coated pits. Thus, cargo proteins may cause functional specialization of vesicle trafficking within the early endocytic pathway.

PMID:
17018271
DOI:
10.1016/j.cell.2006.09.012
[Indexed for MEDLINE]
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