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Protein Pept Lett. 2006;13(7):679-85.

The proline-rich domain and the microtubule binding domain of protein tau acting as RNA binding domains.

Author information

1
State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Rd, Chaoyang District, Beijing 100101, China.

Abstract

Neuronal tau, through its proline-rich domain and the microtubule binding domain, binds to RNA non-sequence-specifically via electrostatic interaction. This binding inhibits the activity of tau. Tau and RNA were also found to co-localize in SH-SY5Y cells suggesting that RNA has opportunities to interact with tau in cells.

PMID:
17018010
DOI:
10.2174/092986606777790566
[Indexed for MEDLINE]

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