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J Clin Invest. 2006 Oct;116(10):2571-9.

Deiodinases: implications of the local control of thyroid hormone action.

Author information

1
Thyroid Section, Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. abianco@partners.org

Abstract

The deiodinases activate or inactivate thyroid hormone, and their importance in thyroid hormone homeostasis has become increasingly clear with the availability of deiodinase-deficient animals. At the same time, heightened interest in the field has been generated following the discovery that the type 2 deiodinase can be an important component in both the Hedgehog signaling pathway and the G protein-coupled bile acid receptor 1-mediated (GPBAR1-mediated) signaling cascade. The discovery of these new roles for the deiodinases indicates that tissue-specific deiodination plays a much broader role than once thought, extending into the realms of developmental biology and metabolism.

PMID:
17016550
PMCID:
PMC1578599
DOI:
10.1172/JCI29812
[Indexed for MEDLINE]
Free PMC Article

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