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Br J Pharmacol. 2006 Nov;149(6):611-23. Epub 2006 Oct 2.

Prostaglandin E2 receptor distribution and function in the gastrointestinal tract.

Author information

1
Department of Microbiology and Infectious Disease, Health Sciences Centre, University of Calgary, Calgary, Alberta, Canada.

Abstract

Prostaglandin E2 (PGE2) is one of the most important biologically active prostanoids found throughout the gastrointestinal tract. Despite the fact that PGE2 regulates many physiological functions of the gut including mucosal protection, gastrointestinal secretion and motility, it is implicated in the pathophysiology of inflammatory bowel diseases (IBD) and colorectal neoplasia. The varied biological functions exerted by PGE2 are through the pharmacologically distinct, G-protein coupled plasma membrane receptors termed EP receptors. Disruptions of various prostanoid receptor genes have helped in unravelling the physiological functions of these receptors. To date, all four subtypes of EP receptors have been individually knocked out in mice and various phenotypes have been reported for each subtype. Similarly, in vitro and in vivo studies using EP receptor agonists and antagonists have helped in uncoupling the diverse functions of PGE2 signalling involving distinct EP receptors in the gut. In this review, we will summarize and conceptualize the salient features of EP receptor subtypes, their regional functions in the gut and how expressions of EP receptors are altered during disease states.

PMID:
17016496
PMCID:
PMC2014644
DOI:
10.1038/sj.bjp.0706923
[Indexed for MEDLINE]
Free PMC Article

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