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Trends Neurosci. 1990 Nov;13(11):447-52.

A common denominator of growth cone guidance and collapse?

Author information

1
Max-Planck-Institut für Entwicklungsbiologie, Tübingen, FRG.

Abstract

Axonal guidance in the retinotectal system and in spinal nerve segmentation is based on repulsion or inhibition. In both systems the membrane glycoprotein responsible for the guiding activity is capable of inducing growth cone collapse. We discuss two models of axonal guidance that correlate axonal guidance and growth cone collapse. The models are applicable to axon guidance by membrane-associated or diffusible stimuli, and are not based on preferential adhesion of axons to certain substrata.

PMID:
1701577
DOI:
10.1016/0166-2236(90)90097-t
[Indexed for MEDLINE]

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