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Am J Psychiatry. 2006 Oct;163(10):1829-31.

Increased expression of activity-dependent genes in cerebellar glutamatergic neurons of patients with schizophrenia.

Author information

1
Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, 87131, USA.

Abstract

OBJECTIVE:

The purpose of this study was to evaluate the functional state of glutamatergic neurons in the cerebellar cortex of patients with schizophrenia.

METHOD:

The authors measured messenger ribonucleic acid (mRNA) levels of three activity-dependent genes expressed by glutamatergic neurons in the cerebellar cortex (GAP-43, BDNF, and GABA OLE_LINK2>(A)-delta subunit) in the tissues of 14 patients with schizophrenia and 14 matched nonpsychiatric comparison subjects. Since its level of expression does not change in response to neuronal activity, gamma-aminobutyric acid(A)-alpha6 subunit mRNA was used as a control.

RESULTS:

The levels of GAP-43 and BDNF mRNAs were significantly elevated in patients with schizophrenia, and a similar finding was observed for GABA(A)-delta mRNA. In contrast, the levels of the GABA(A)-alpha6 subunit mRNA, which is expressed in cerebellar granule cells in an activity-independent manner, did not differ from comparison subjects.

CONCLUSIONS:

These results suggest that glutamatergic neurons may be hyperactive in the cerebellar cortices of patients with schizophrenia.

PMID:
17012697
DOI:
10.1176/ajp.2006.163.10.1829
[Indexed for MEDLINE]

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