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Dev Cell. 2006 Oct;11(4):433-4.

mTORC2 Caught in a SINful Akt.

Author information

1
Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.

Abstract

The target of rapamycin (TOR), a central controller of cell growth, is found in two distinct, highly conserved multiprotein complexes. Three recent papers in Cell (Jacinto et al., 2006), Developmental Cell (shiota et al., 2006; this issue), and Current Biology (Frias et al., 2006) shed light on mTOR complex 2 (mTORC2) composition and in vivo function. An important new finding is that mTORC2 determines Akt/PKB substrate specificity rather than absolute activity.

PMID:
17011481
DOI:
10.1016/j.devcel.2006.09.005
[Indexed for MEDLINE]
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