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Int J Radiat Oncol Biol Phys. 2006 Nov 1;66(3):637-46.

ReVOLT: radiation-enhanced viral oncolytic therapy.

Author information

  • 1Department of Radiation and Cellular Oncology, the University of Chicago, Chicago, IL 60637, USA.

Abstract

Viral oncolytic therapy has been pursued with renewed interest as the molecular basis of carcinogenesis and viral replication has been elucidated. Genetically engineered, attenuated viruses have been rationally constructed to achieve a therapeutic index in tumor cells compared with surrounding normal tissue. Many of these attenuated mutant viruses have entered clinical trials. Here we review the preclinical literature demonstrating the interaction of oncolytic viruses with ionizing radiation and provides a basis for future clinical trials.

PMID:
17011442
DOI:
10.1016/j.ijrobp.2006.06.034
[PubMed - indexed for MEDLINE]
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