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Prenat Diagn. 2006 Dec;26(12):1137-41.

First-trimester maternal dried blood Down syndrome screening marker levels in early pregnancy loss.

Author information

1
Research Division, NTD Laboratories, Huntington Station, NY 11746, USA. dakrantz@ntdlabs.com

Abstract

OBJECTIVE:

To determine the association of free beta hCG and PAPP-A measured during first-trimester Down syndrome risk assessment with early pregnancy loss when blood is drawn prior to scheduled ultrasound.

METHODS:

Maternal dried blood samples were collected prior to the ultrasound exam for Down syndrome risk assessment. Free beta hCG and PAPP-A levels in 55 patients who experienced loss of pregnancy prior to their scheduled ultrasound appointment were compared to 6464 control pregnancies using logistic regression.

RESULTS:

Low levels of free beta hCG and PAPP-A were associated with increased risk of early pregnancy loss. The detection rate of early pregnancy loss for a fixed 5% false-positive rate using free beta alone, PAPP-A alone and a combination of the two were 47, 36 and 49%, respectively.

CONCLUSION:

Free beta hCG and PAPP-A can identify pregnancies at increased risk for early pregnancy loss. More studies are needed to determine whether further evaluation of these pregnancies prior to the scheduled ultrasound is warranted.

PMID:
17009346
DOI:
10.1002/pd.1574
[Indexed for MEDLINE]

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