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Nat Rev Mol Cell Biol. 2006 Nov;7(11):813-9. doi: 10.1038/nrm2030. Epub 2006 Sep 27.

Linking data to models: data regression.

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Department of Cell Biology, the Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.


Mathematical models are an essential tool in systems biology, linking the behaviour of a system to the interactions between its components. Parameters in empirical mathematical models must be determined using experimental data, a process called regression. Because experimental data are noisy and incomplete, diagnostics that test the structural identifiability and validity of models and the significance and determinability of their parameters are needed to ensure that the proposed models are supported by the available data.

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