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Indian J Med Sci. 2006 Oct;60(10):417-20.

Angiotensin converting enzyme inhibitors and aortic arch obstructive malformations.

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  • 1Department of Neonatology, Tehran University of Medical Sciences, Children's Medical Center, Tehran, Iran.


We describe two newborn infants with aortic arch obstructive malformations who became anuric after initiation of captopril. Since angiotensin converting enzyme inhibitors can alter renal blood flow by reduction in angiotensin II and blocking autoregulation phenomenon, it is important to use them with great caution in neonates with aortic arch obstructive malformations, while monitoring their renal function closely.

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