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Antimicrob Agents Chemother. 2006 Oct;50(10):3464-6.

Efficacy of ambruticin analogs in a murine model of invasive pulmonary aspergillosis.

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1
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.

Abstract

Ambruticins are a family of polyketides. The antifungal activity of an ambruticin, KOSN-2079, was tested in the mouse model of invasive aspergillosis. KOSN-2079 significantly reduced pulmonary fungal burdens and improved survival over that with the vehicle control. These results support the continued development of ambruticins as antifungal agents.

PMID:
17005833
PMCID:
PMC1610070
DOI:
10.1128/AAC.00558-06
[Indexed for MEDLINE]
Free PMC Article
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