Format

Send to

Choose Destination
Virus Res. 2007 Feb;123(2):211-5. Epub 2006 Sep 26.

Sequence variability of retroviral particles derived from human melanoma cells melanoma-associated retrovirus.

Author information

1
Department of Dermatology, Division of General Dermatology, University of Vienna Medical School, Währinger Gürtel 18-20, Vienna, Austria. sonja.hirschl@mci.edu

Abstract

We have shown that melanoma cells produce viral particles that contain sequences which are homologous to human endogenous retroviruses. In this study particles derived from different melanoma cell lines and from melanoma cells of a lymph node metastasis were characterized. We determined the density and the reverse transcriptase (RT) activity of viral particles. Furthermore, we analyzed the sequence variability of multiple clones of each particle preparation. The particles were found to package sequences, which vary for each of the analyzed cell lines. Moreover, even particles derived from the same cell line contain heterologous sequences.

PMID:
17005285
DOI:
10.1016/j.virusres.2006.08.010
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center