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Korean J Ophthalmol. 2006 Sep;20(3):162-5.

Transforming growth factor-beta levels in human aqueous humor of glaucomatous, diabetic and uveitic eyes.

Author information

1
Department of Ophthalmology, Kim's Eye Hospital, Myung-Gok Eye Research Institute, Konyang University College of Medicine, Seoul, Korea.

Abstract

PURPOSE:

Transforming growth factor-beta2 is known to be present at elevated levels in the aqueous humor of patients with primary open angle glaucoma (POAG) and diabetes but not in uveitis-related secondary glaucoma. We investigated total TGF-beta2 levels and levels of the active form of TGF-beta2 in the aqueous humor of eyes with different types of glaucoma.

METHODS:

The concentration of the total and active form of TGF-beta2 was measured in 63 patients with primary open angle glaucoma, neovascular glaucoma complicated with diabetes (NVG), and secondary open angle glaucoma complicated with uveitis (SOAG) using a double antibody 'sandwich-indirect' ELISA method.

RESULTS:

The levels of total TGF-beta2 in the aqueous samples of POAG, NVG, and SOAG were elevated. The levels of active TGF-beta2 in the aqueous samples of POAG, and NVG were also elevated, whereas the level of active TGF-beta2 was within the normal range in the aqueous samples of SOAG.

CONCLUSIONS:

These results suggest that the level of TGF-beta2 may play a role in the pathology of various types of glaucoma.

PMID:
17004630
PMCID:
PMC2908840
DOI:
10.3341/kjo.2006.20.3.162
[Indexed for MEDLINE]
Free PMC Article

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