Format

Send to

Choose Destination
Br J Cancer. 2006 Nov 20;95(10):1415-8. Epub 2006 Sep 26.

Are microRNAs located in genomic regions associated with cancer?

Author information

1
Bioinformatics Research Center (BiRC), University of Aarhus, Hoegh-Guldbergs Gade 10, Bldg 1090, Aarhus C, Denmark.

Abstract

We report on the location of 283 miRNAs in the human genome in relation to copy number changes in three distinct types of tumours: prostate, bladder and colon. In prostate and colon tumours, we find miRNAs over-represented in regions with copy number gain and under-represented in regions with copy number loss. Surprisingly this pattern appears to be reversed in bladder cancer. We compared our miRNA copy number data to published miRNA expression data; unexpectedly, we did not find a statistically significant relationship between miRNA copy number and expression level. This suggests that miRNA expression is regulated through different mechanisms than mRNA expression.

PMID:
17003783
PMCID:
PMC2360608
DOI:
10.1038/sj.bjc.6603381
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center