Send to

Choose Destination
See comment in PubMed Commons below
Br J Cancer. 2006 Nov 6;95(9):1288-90. Epub 2006 Sep 26.

Family history and risk of lung cancer: age-at-diagnosis in cases and first-degree relatives.

Author information

  • 1Roy Castle Lung Cancer Research Programme, University of Liverpool Cancer Research Centre, 200 London Road, Liverpool L3 9TA, UK.


To investigate the little known risk of lung cancer at an early age when a first-degree relative has had such a diagnosis, 579 incident cases and 1157 population controls were studied in Liverpool between 1998 and 2004 using standardised questionnaires covering demography and lifestyle. A history of lung cancer in first-degree relatives was associated with a significantly increased risk in the proband where in both individuals the cancers were diagnosed before the age of 60 years (odds ratio (OR)=4.89; 95% confidence interval (CI): 1.47-16.25). A significantly elevated risk of lung cancer was also observed in association with a relative affected before the age of 60 years, regardless of age-at-onset of the disease (OR=2.08; 95% CI: 1.20-3.59). This finding is strongly consistent with a genetic component in early-onset lung cancer risk.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Support Center