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IUBMB Life. 2006 Sep;58(9):508-14.

RNase L: its biological roles and regulation.

Author information

1
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.

Abstract

2'-5'oligoadenylate-dependent ribonuclease L (RNase L) is one of the key enzymes involved in the function of interferons (IFNs), a family of cytokines participating in innate immunity against viruses and other microbial pathogens. Upon binding with its activator, 5'-phosphorylated, 2'-5' linked oligoadenylates (2-5A), RNase L degrades single-stranded viral and cellular RNAs and thus plays an important role in the antiviral and antiproliferative functions of IFNs. In recent years, evidence has revealed that RNase L displays a broad range of biological roles which are summarized in this review.

PMID:
17002978
DOI:
10.1080/15216540600838232
[Indexed for MEDLINE]
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