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Int J Med Microbiol. 2006 Dec;296(8):559-62. Epub 2006 Sep 26.

Use of DNA arrays for the analysis of outbreak-related strains of Listeria monocytogenes.

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Laboratoire des Listeria, Centre National de Référence des Listeria, World Health Organisation Collaborating Center for Foodborne Listeriosis, Institut Pasteur, 25-28 rue du Dr Roux, F-75724 Paris Cedex 15, France.


We evaluated the discriminative power and usefulness of the DNA array technology as compared to DNA macrorestriction pattern analysis for monitoring epidemiologically related clusters of Listeria monocytogenes strains that differ slightly in DNA macrorestriction patterns. We show that this approach allows clarifying the genetic basis of the pattern variations. In the reported outbreak, the differences were due to phage excision, showing the power of this technique in epidemiological studies.

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