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Nat Neurosci. 2006 Oct;9(10):1221-5.

Fragile X syndrome and autism at the intersection of genetic and neural networks.

Author information

1
Department of Human Development, Cornell University, Martha Van Rensselaer Hall, Ithaca, New York 14853-4401, USA. belmonte@mit.edu

Abstract

Autism, an entirely behavioral diagnosis with no largely understood etiologies and no population-wide biomarkers, contrasts with fragile X syndrome (FXS), a single-gene disorder with definite alterations of gene expression and neuronal morphology. Nevertheless, the behavioral overlap between autism and FXS suggests some overlapping mechanisms. Understanding how the single-gene alteration in FXS plays out within complex genetic and neural network processes may suggest targets for autism research and illustrate strategies for relating autism to more singular genetic syndromes.

PMID:
17001341
DOI:
10.1038/nn1765
[Indexed for MEDLINE]

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