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Clin Cancer Res. 2006 Sep 15;12(18):5268-72.

The epidermal growth factor receptor pathway: a model for targeted therapy.

Author information

1
Medical Oncology Service, Vall d'Hebron University Hospital and Universidad Autónoma de Barcelona, Barcelona, Spain.

Abstract

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase receptor that is frequently expressed in epithelial tumors. The EGFR was the first receptor to be proposed as a target for cancer therapy, and after 2 decades of intensive research, there are several anti-EGFR agents available in the clinic. Recent advances in our understanding in the mechanisms of receptor activation and function, discovery of primary and secondary EGFR somatic mutations, as well as a new generation of anti-EGFR agents provide new leads on the clinical targeting of this receptor and may serve as a model for strategies aimed at targeting other receptors.

PMID:
17000658
DOI:
10.1158/1078-0432.CCR-05-1554
[Indexed for MEDLINE]
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