Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Rev Immunol. 2006 Oct;6(10):751-60.

Reciprocal regulation between natural killer cells and autoreactive T cells.

Author information

1
Barrow Neurological Institute, Saint Joseph's Hospital and Medical Center, Phoenix, Arizona 85013, USA. fu-dong.shi@chw.edu

Abstract

The initiation and the progression of autoimmune diseases stem from complex interactions that involve cells of both the innate and the adaptive immune system. As we discuss here, natural killer (NK) cells, which are components of the innate immune system, can inhibit or promote the activation of autoreactive T cells during the initiation of autoimmunity. After they have been activated, autoreactive T cells contribute to the homeostatic contraction of NK-cell populations. The dynamic interaction between NK cells and autoreactive T cells might indicate the transition from the innate immune triggering of autoimmunity to the progressive phase of the disease. Understanding the mechanisms and signals that control the reciprocal regulation of NK cells and autoreactive T cells could have important implications for treatment in the clinic.

PMID:
16998508
DOI:
10.1038/nri1935
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center