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Eur J Pharmacol. 1990 Aug 21;185(1):99-102.

Glutamate-induced inward current in a clonal neuroblastoma cell line.

Author information

1
Research Institute of Toxicology, University of Utrecht, The Netherlands.

Abstract

The presence of glutamate-induced electrophysiological responses was examined in eight clonal neuroblastoma cell lines with the whole-cell voltage clamp technique. Only N2A cells responded to glutamate superfusion with a concentration-dependent, reversible inward current. Superfusion with the analogues kainic acid, quisqualic acid and N-methyl-D-aspartic acid also evoked inward currents but they had a smaller amplitude. The results indicate that N2A neuroblastoma cells could serve as an in vitro model to study the functional properties of glutamate receptors and associated ion channels.

PMID:
1699769
DOI:
10.1016/0014-2999(90)90215-r
[Indexed for MEDLINE]

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