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Trends Genet. 2006 Dec;22(12):671-7. Epub 2006 Sep 25.

Altering nucleosomes during DNA double-strand break repair in yeast.

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Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, 915 Camino de Salud, Albuquerque, NM 87131, USA.


Although chromatin remodeling has a key role in the regulation of gene expression, it is also important for other chromatin-based processes such as DNA repair, replication and recombination. ATP-dependent chromatin remodeling factors have unique roles in disrupting histone-DNA interactions and are targeted to gene promoters to 'loosen' chromatin for access of transcription factors. Recently, three chromatin remodeling factors with roles in transcriptional regulation have also been shown to be present at sites of DNA double-strand breaks (DSBs) in yeast. These factors control different aspects of DSB repair, suggesting that chromatin remodeling constitutes a key mechanism to preserve genome integrity.

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