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Drug Discov Today. 2006 Oct;11(19-20):905-10. Epub 2006 Sep 7.

Is the oral route possible for peptide and protein drug delivery?

Author information

1
Department of Pharmaceutics, Hoshi University, Ebara 2-4-41, Shinagawa, Tokyo 142-8501, Japan. morisita@hoshi.ac.jp

Abstract

Oral delivery of peptides and proteins remains an attractive alternative to parenteral delivery and has challenged various attempts at delivery development. Incorporation of new tools into the delivery systems that can raise membrane permeability of macromolecules is essential to attain high oral bioavailability that is acceptable in clinical applications. In developing oral protein delivery systems with high bioavailability, three practical approaches might be most helpful: (1) modification of the physicochemical properties of macromolecules; (2) addition of novel function to macromolecules; or (3) use of improved delivery carriers. Clearly, it is essential that these approaches maintain the biological activity of the proteins.

PMID:
16997140
DOI:
10.1016/j.drudis.2006.08.005
[Indexed for MEDLINE]
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