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Trends Cell Biol. 2006 Nov;16(11):547-9. Epub 2006 Sep 25.

A CLOCK-less clock.

Author information

1
Department of Molecular Biology, Sciences III, University of Geneva, 30 Quai Ernest Ansermet, CH-1211 Geneva-4, Switzerland.

Abstract

Mammalian physiology is governed by a complex circadian timing system that involves interacting positive and negative transcriptional feedback loops. A key role in this feedback loop was attributed to the PAS domain helix-loop-helix protein CLOCK, on the basis of a dominant-negative mutation in this transcription factor. However, recent experiments by Reppert and coworkers with Clock knockout mice suggest that CLOCK is dispensable for rhythmic gene expression and behavior, presumably because other proteins can substitute for CLOCK in these animals.

PMID:
16996737
DOI:
10.1016/j.tcb.2006.09.005
[Indexed for MEDLINE]

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