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Gastrointest Endosc. 2006 Oct;64(4):544-52.

A randomized prospective trial comparing different regimens of oral sodium phosphate and polyethylene glycol-based lavage solution in the preparation of patients for colonoscopy.

Author information

1
Division of Gastroenterology, The Ottawa Hospital, University of Ottawa, Ottawa, Canada.

Abstract

BACKGROUND:

Regulatory agencies have warned clinicians regarding the risk of electrolyte abnormalities if more than two 45-mL bottles of oral sodium phosphate (NaP) solution are administered within a 24-hour period.

OBJECTIVE:

To compare the efficacy, safety, and tolerability of different regimens of oral NaP and polyethylene glycol (PEG).

DESIGN:

Randomized controlled trial.

SETTING:

Teaching hospital outpatient endoscopy clinic.

PATIENTS:

Two hundred outpatients without comorbidities who underwent routine colonoscopy.

INTERVENTIONS:

Two bottles of NaP, 6, 12, or 24 hours apart; or 4 L PEG.

MAIN OUTCOME MEASUREMENTS:

Bowel preparation quality, patient tolerability, and electrolyte changes.

RESULTS:

The 12- and 24-hour NaP achieved better cleansing than the 6-hour NaP or PEG. Only 8.5% and 8.3% of patients in the 24- and 12-hour NaP had poor preparations, respectively, compared with 15.6% and 23.4% in the 6-hour NaP and PEG, respectively. The poorer preparation scores with PEG were partly because of a greater amount of colonic fluid. There were no relevant electrolyte changes with PEG, whereas hypokalemia, hypocalcemia, or hyperphosphatemia developed in 5% to 57% of patients on NaP. All regimens were poorly tolerated by patients.

LIMITATIONS:

The study was likely underpowered to detect small group differences in electrolytes.

CONCLUSIONS:

A 24- or 12-hour NaP bowel preparation strategy was more effective than NaP 6 hours apart or PEG. PEG use is associated with more residual colonic fluid but represents an alternative to NaP in some clinical situations.

Comment in

PMID:
16996347
DOI:
10.1016/j.gie.2005.09.030
[Indexed for MEDLINE]

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