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Biochim Biophys Acta. 1990 Oct 23;1087(2):250-2.

Manganese superoxide dismutase: nucleotide and deduced amino acid sequence of a cDNA encoding a new human transcript.

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Department of Pediatrics, St. Louis Children's Hospital, Washington University School of Medicine, MO 63110.

Erratum in

  • Biochim Biophys Acta 1993 Jan 23;1171(3):341.


Three human cDNA libraries were screened with a human manganese superoxide dismutase (Mn-SOD) cDNA under moderately stringent conditions to characterize a large 4-6 kb RNA species which hybridizes to Mn-SOD in RNA blot analyses. A new 4.2 kb Mn-SOD cDNA clone (Mn-SOD 1) was isolated. Its long 3426 nucleotide 3'-untranslated sequence contains both of the 240 base 3'-untranslated sequences of the 1 kb Mn-SOD 4 and 5 cDNAs. This is a fully processed, cytoplasmic RNA species and raises the possibility of a role for particular 3'-untranslated sequence selection in Mn-SOD gene regulation.

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